Thursday, January 18, 2007

Columbia University licenses next-generation DNA sequencing technology

Columbia University announces today that it recently executed an
exclusive license agreement for a next generation DNA sequencing
technology to Intelligent Bio-Systems (IBS), Inc. This innovative
DNA-sequencing technology was invented by Dr. Jingyue Ju, professor of
Chemical Engineering and head of DNA Sequencing and Chemical Biology at
the Judith P. Sulzberger, M.D. Columbia Genome Center at Columbia
University. The fundamentals of this new technology are being published
on-line today by in the Proceedings of the National Academy of Sciences
(PNAS). This research paper describes the details of the Sequencing by
Synthesis Chemistry and how the approach overcomes accuracy limitations
of other next generation DNA sequencing systems.

It was also recently announced that Columbia University in
collaboration with the Waltham, Mass. based Intelligent Bio-Systems, is
one of only two recipients of the Near-Term Technology Development for
Genome Sequencing grants from the National Human Genome Research
Institute (NHGRI) of the National Institutes of Health (NIH)
( This grant of $425,000 is for the
development of a "High-Throughput DNA Sequencing by Synthesis Platform."

"The collaboration between Dr. Ju at Columbia and Intelligent
Bio-Systems is an important development to bring this powerful
technology to both researchers and clinicians in the near future," said
Dr. Steven Gordon, Chief Executive Officer at IBS. "Completing the
license was a key step in uniting Dr. Ju's seminal sequencing chemistry
and IBS's molecular biology and engineering expertise. We are poised to
offer a simple, cost effective platform that will enable many
researchers and clinicians to use this next-generation DNA sequencing
technology in their own laboratories."

Dr. Ju is a prolific inventor of new technologies for
applications in genomics using chemistry and molecular engineering
approaches. He is credited with being one of the primary inventors of
the fluorescent energy transfer chemistry for 4-color Sanger sequencing
being used by virtually all of the current generations of DNA
sequencers that were used to complete the Human Genome Project.


About Columbia Genome Center

From its conception in 1995, the Judith P. Sulzberger, M.D.,
Columbia Genome Center (CGC) has served as a bridge between the
biomedical and science/engineering communities of the two Columbia
University campuses, the main campus in Morningside Heights and the
Medical Center campus in Washington Heights. The CGC was born as an
interdisciplinary consortium of scientists and engineers dedicated to
the generation of technology, information science, systems biology, and
population genetic theory required to transform information from the
genome to the study of biology and the practice of medicine. Today,
more than 70 scientists collaborate on initiatives to further
illuminate the genome.

About Columbia University

Founded in 1754 as King's College, Columbia University in the
City of New York is the fifth oldest institution of higher learning in
the United States and is one of the world's leading academic and
research institutions, conducting pathbreaking research in medicine,
science, engineering, the arts, and the humanities. For more
information about Columbia University, visit

About Intelligent Bio-Systems, Inc.

Intelligent Bio-Systems, Inc. is a privately held company
located in Waltham, Mass. Since founding in 2005 it has focused on the
development of next-generation DNA sequencing, gene expression and
diagnostic systems based on proprietary instruments, chemistry, and
consumables. The company has committed to deliver working instruments
to the laboratories of a few early access collaborators during the
coming year.

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Columbia University licenses next-generation DNA sequencing technology

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